Fig. 3.

Deletion of integrin α5 in osteocytes attenuated or reversed the anabolic function of mechanical loading in midshaft cortical bone. μCT analysis of the mid-diaphyseal region located 37% from the proximal end, for both loaded and contralateral, unloaded tibias of WT and cKO mice: a total cross-sectional area (T.Ar), b bone area (B.Ar), c bone area fraction (B.Ar/T.Ar), d bone marrow area (M.Ar), e cortical thickness (Ct.Th), f polar moment of inertia (pMOI), and g bone mineral density (BMD). n = 8 per group. j Representative 3D models of the cortical bone for WT and cKO mice. Three-point bending test was performed for tibias bones of WT and cKO mice: h elastic modulus and i ultimate stress. n = 7 per group. Mean ± SD. *P < 0.05; **P < 0.01. Paired t test was used for loaded and contralateral tibias and unpaired t test for loaded or control tibias between WT and cKO mice