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. 2022 Jul 19;55(9):1732–1746.e5. doi: 10.1016/j.immuni.2022.07.005

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© 2022 The Author(s)

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Phenotypic evolution of shared CD8⁺ T cell clones at 6 months post-vaccination

(A) Stacked bar plot of the proportion of the CD8⁺ T cell repertoire with paired clonotype (CDR3) identity from each donor observed at only one or both time points. The dividing line represents the contribution of clonotypes from each time point for each donor.

(B) Dot plot of the frequency of only cells with clonotype identity observed in both time points. Identical clonotypes are connected.

(C) Violin plots of the protein expression of CD45RA and CCR7 in cells with clonotype identity observed in both time points.

(D) UMAP visualization of the distribution of cells with clonotype identity observed in only two or both time points.

(E) Violin plot of the cytotoxic module score in cells with clonotype identity observed in both time points.

(F) Volcano plot of differentially expressed cells' genes from day 35 and 6 months with shared clonotypes.

(G) GSEA of C7 immunologic signature gene sets using the ranked set of differentially expressed genes between shared clonotypes from day 35 and 6 months.

(C, E, and F) Mann-Whitney test. (G) GSEA permutation test. See also Figure S6.