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. 2022 Jul 18;12:286. doi: 10.1038/s41398-022-02059-w

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2022

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Fig. 1 — A, B PIMSR failed to alter cocaine self-administration under FR1 reinforcement (n = 8), but dose-dependently inhibited cocaine self-administration under FR5 reinforcement in a separate group of rats (n = 8). C PIMSR significantly inhibited cocaine self-administration maintained by low-dose cocaine (0.03, 0.06, 0.12, 0.25 mg/kg/infusion) under FR2 reinforcement and shifted the cocaine dose-response curve downward (n = 8). D PIMSR dose-dependently reduced cocaine intake calculated from the data in C (i.e., sum of cocaine dose × infusions at each cocaine dose). *p < 0.05, **p < 0.01, compared to vehicle.