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. 2022 Jul 18;12:286. doi: 10.1038/s41398-022-02059-w

Fig. 2. The effect of PIMSR on PR cocaine self-administration and FR1 oral sucrose self-administration.

Fig. 2

A, B PIMSR inhibited cocaine self-administration under PR reinforcement in a dose-dependent manner (n = 7), as assessed by the number of cocaine infusions (A) and break-point (B). C, D PIMSR dose-dependently inhibited oral sucrose self-administration under FR1 reinforcement (n = 6), as assessed by the number of sucrose deliveries (C) and active lever responses (D). PIMSR did not alter inactive lever responses. *p < 0.05, ***p < 0.001, compared to vehicle.