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. 2022 Jul 18;12:286. doi: 10.1038/s41398-022-02059-w

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2022

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Fig. 6 — A A diagram showing the experimental methods for oICSS. B Representative images of TH-immunostaining (red) and fluorescent ChR2-eYFP expression (green) in the VTA, illustrating TH and ChR2-eYFP colocalization in VTA DA neurons. C Systemic administration of PIMSR inhibited optical ICSS (n = 8). D Δ⁹-THC alone also inhibited oICSS at a high dose (3.5 mg/kg) and shifted the stimulation-response curve downward (n = 7). E Pretreatment with PIMSR failed to significantly alter Δ⁹-THC-induced reduction in oICSS (n = 7). F However, the AUC assays for the data shown in E revealed a significant reduction in Δ⁹-THC’s action on oICSS after PIMSR pretreatment. G PIMSR also attenuated ACEA-induced reduction in oICSS (n = 6). H The AUC assays for the data shown in G revealed a significant reduction in ACEA action on oICSS after 3 mg/kg PIMSR pretreatment. *p < 0.05, compared to vehicle at each stimulation frequency. #p < 0.05, compared to Δ⁹-THC or ACEA treatment group.