. 2022 Jul 18;5:691. doi: 10.1038/s42003-022-03607-2

Table 5.

Summary of MR analysis results for AD and GIT disorders.

Exposure (nSNPs)	Outcome	IVW		Weighted median		MR-Egger		MR-PRESSO					MR-Egger Intercept
Exposure (nSNPs)	Outcome	Beta	P	Beta	P	Beta	P	Global test P	Raw beta	P	Corrected beta	P	Intercept	P
AD (28)	GERD	−0.053	0.266	0.011	0.860	−0.059	0.362	0.113	−0.052	0.276	—	—	0.00034	0.879
GERD (24)	AD	0.014	0.351	−0.002	0.920	−0.053	0.597	0.435	0.0136	0.361	—	—	0.0025	0.502
AD (28)	PUD	0.036	0.651	0.144	0.211	0.071	0.504	0.113	0.036	0.60	—	—	−0.002	0.612
PUD (8)	AD	0.021	0.238	0.025	0.122	0.055	0.658	0.0104	0.021	0.277	0.0331	0.053	−0.00291	0.770
AD (28)	PGM	−0.061	0.112	−0.016	0.769	−0.045	0.391	0.231	−0.061	0.123	—	—	−0.001	0.631
PGM (17)	AD	0.023	0.322	−0.005	0.837	−0.148	0.199	0.017	0.023	0.337	0.009	0.661	0.007	0.133
AD (28)	Gastritis-D^a	−0.085	0.267	−0.101	0.273	−0.173	0.098	0.034	−0.085	0.277	—	—	0.0046	0.196
AD (28)	IBS^a	0.043	0.623	0.142	0.123	−0.016	0.888	0.0012	0.043	0.626	0.010	0.892	0.0032	0.438
AD (28)	Diverticular	−0.055	0.597	−0.214	0.105	−0.12	0.397	0.094	−0.055	0.601	—	—	0.0034	0.483
Diverticular (16)	AD	−0.001	0.883	−0.001	0.905	0.007	0.811	0.316	−0.001	0.884	—	—	−0.00076	0.773
AD (28)	IBD	0.254	0.104	0.365	0.094	0.277	0.231	0.327	0.254	0.115	—	—	−0.00097	0.885
IBD (24)	AD	−0.0005	0.895	−0.003	0.526	0.004	0.607	0.316	−0.0005	0.895	—	—	0.00073	0.497

nSNP number of SNPs utilised as instrumental variables, SNP single-nucleotide polymorphism, AD Alzheimer’s disease, GERD gastroesophageal reflux disease, PUD peptic ulcer disease, PGM GWAS combining disease-diagnosis of PUD and/or GERD and/or medications for their treatments, Diverticular diverticular disease, IBS irritable bowel syndrome, IBD inflammatory bowel disease, IVW inverse variance weighted, P P value, MR-PRESSO Mendelian Randomization Pleiotropy RESidual Sum and Outlier, Gastritis-D gastritis-duodenitis.

^aOnly one genome-wide significant SNPs available for IBS, and 3 for Gastritis-D, so we are unable to carry out MR using the traits as the exposure variable. Note spaces marked with a dash indicate that there were no outlier SNPs and hence there was no outlier corrected results in the MR-PRESSO analysis.