. 2022 Jul 18;12:12237. doi: 10.1038/s41598-022-16379-w

Table 5.

Predictors of Composite Endpoints, overall mortality and hospitalization for heart failure in patients with Chagas Disease.

Variable	Hospitalization for Heart Failure			Death			Composite Endpoints
Variable	p	HR	95% CI	p	HR	95% CI	p	HR	95% CI
LA Diameter	0.002	1.188	1.063–1.328	0.015	1.093	1.018–1.174	< 0.001	1,121	1,055–1,192
LA volume	< 0.001	1.060	1.030–1.092	< 0.001	1.026	1.011–1.041	< 0.001	1,027	1,015–1,040
LA indexed volume (ml/m²)	< 0.001	1.061	1.03–1.092	< 0.001	1.052	1.025–1.087	< 0.001	1,05	1,028–1,072
RA area (cm²)	< 0.001	1.183	1.086–1.289	< 0.001	1.144	1.070–1.224	< 0.001	1,206	1,12–1,29
RA volume (ml)	< 0.001	1.030	1.015–1.045	< 0.001	1.026	1.013–1.039	< 0.001	1,036	1,022–1,049
TAPSE (mm)	0.12	0.853	0.699–1.041	0.02	0.850	0.740–0.976	0.009	0,854	0,76–0,96
RV S´ wave (cm/s)	0.006	0.682	0.521–0.894	0.05	0.823	0.678–1.000	0.003	0,784	0,669–0,92
FAC	0.002	0.001	0.000–0.064	0.06	0.040	0.001–1.070	0.001	0,008	0,001–0,128
LVDD (mm)	< 0.001	1.147	1.063–1.238	< 0.001	1.123	1.063–1.186	< 0.001	1,167	1,107–1,229
LVSD (mm)	0.001	1.118	1.044–1.197	< 0.001	1.104	1.055–1.156	< 0.001	1,123	1,077–1,171
RWT	0.001	0.000	0.000–0.000	< 0.001	0.000	0.000–0.003	< 0.001	0.000	0,00–0,00
LVEDV (ml)	0.001	1.011	1.005–1.017	< 0.001	1.011	1.005–1.016	< 0.001	1,013	1,009–1,017
LVESV (ml)	< 0.001	1.013	1.006–1.021	< 0.001	1.013	1.007–1.019	< 0.001	1,016	1,011–1,021
Indexed Myocardial Mass (g/m²)	0.025	1.021	1.003–1.039	< 0.001	1.026	1.013–1.040	< 0.001	1,027	1,016–1,038
LVEF (Simpson)	0.004	0.000	0.000–0.031	< 0.001	0.000	0.000–0.014	< 0.001	0.000	0,000–0,003
LVDV indexed (ml)	0.002	1.017	1.007–1.029	< 0.001	1.020	1.010–1.030	< 0.001	1,021	1,014–1,029
LVSV indexed (ml)	< 0.001	1.022	1.010–1.034	< 0.001	1.023	1.012–1.034	< 0.001	1,026	1,017–1,035
E wave (cm/s)	0.001	1.051	1.02–1.084	0.002	1.038	1.013	< 0.001	1,038	1,018–1,059
A wave (cm/s)	0.032	0.942	0.893.0.995	0.06	0.972	0.943–1.001	0.021	0,97	0,945–0,995
Septal e´ (cm/s)	0.021	0.65	0.451–0.937	0.002	0.692	0.546–0.875	0.001	0,713	0,587–0,867
Lateral e´ (cm/s)	0.018	0.732	0.564–0.948	< 0.001	0.694	0.574–0.839	< 0.001	0,714	0,609–0,836
Mean E/e´ratio	< 0.001	1.076	1.035–1.119	< 0.001	1.055	1.025–1.085	< 0.001	1,059	1,033–1,086
Global RV longitudinal strain (%)	0.002	1.220	1.075–1.384	0.001	1.152	1.056–1.257	< 0.001	1,158	1,076–1,245
RV free wall Longitudinal strain (%)	0.02	1.048	1.0 – 1.099	0.04	1.04	1.002–1.079	0.04	1.037	1.005–1.070
2D GLS (%)	< 0.001	1,493	1.199–1,858	< 0.001	1.242	1.116–1.381	< 0.001	1,317	1,184–1,465
2D GCS (%)	0.008	1,427	1.097–1.857	< 0.001	1.447	1.197–1.750	< 0.001	1,329	1,147–1,539
2D GRS (%)	0.98	1,001	0,932–1,075	0.38	0.975	0.92–1.032	0,92	0,998	0,957–1,041
3D LA indexed volume (ml)	< 0.001	1,075	1.033–1.118	< 0.001	1.058	1.029–1.088	< 0.001	1,054	1,029–1,079
3D LVEF (%)	0.004	0,000	0.000–0.032	< 0.001	0.000	0.000–0.008	< 0.001	0.000	0,000–0,002
3D GLS (%)	0.012	1,146	1,03–1,275	< 0.001	1.197	1.090–1.314	< 0.001	1,186	1,102–1,276
3D GCS (%)	0.09	1,066	0,99–1,147	0.005	1.076	1.022–1.132	0.01	1,062	1,015–1,112
Area Strain (%)	0.009	1,107	1,026–1,194	< 0.001	1.155	1.076–1.239	< 0.001	1,123	1,067–1,083
3D GRS	0.009	0,933	0,885–0,992	< 0.001	0.914	0.871–0.959	< 0.001	0,932	0,901–0,964

HR hazard ratio, CI confidence interval. *Values of p < 0.05 indicate statistical significance.

FAC fractional area change, LA left atrium, LV left ventricle, LVDD left ventricular diastolic diameter, LVDV left ventricular diastolic volume, LVEDV left ventricular end-diastolic volume, LVEDV left ventricular end-systolic volume, LVEF left ventricular ejection fraction, LVSD left ventricular systolic diameter, LVDV left ventricular diastolic diameter, RA right atrium, RV right ventricle, RWT relative wall thickness, TAPSE tricuspid annular plane systolic excursion.