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. 2022 Jul 18;12:12258. doi: 10.1038/s41598-022-16506-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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TAC alters the cardiac metabolomic landscape. (A) PCA of the metabolomics data from hearts four weeks post-surgery across all groups [WT sham (n = 10), WT TAC (n = 6), SIRT5OE sham (n = 6) and SIRT5OE TAC (n = 4)]. (B) Succinate levels. (C-D) Immunoblot analysis of Ksucc in sham and TAC mice, with quantification. Statistical significance was determined using two-way ANOVA followed by Sidak’s correction for multiple comparisons for 4-group analyses. Original immunoblot images are presented in Supplemental Fig. 10A.