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. 2022 Jul 18;12:12258. doi: 10.1038/s41598-022-16506-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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SIRT5OE protects against TAC-induced fibrosis four weeks after surgery. (A) Heat map of gene ontology analysis of WT (sham vs TAC) and SIRT5OE (sham vs TAC) mapping to cardiovascular disease related pathways using IPA. Blue color scale represents -log(p-value) of each pathway. (B) GSEA of SIRT5OE TAC compared to WT TAC RNA-seq samples. NES: normalized enrichment score. FDR: false discovery rate. (C) Volcano plot highlighting significant genes in from the GO: collagen containing extracellular matrix gene list. (D) Quantification of the amount of fibrosis in each heart sample, expressed in percentage [WT sham (n = 3), WT TAC (n = 4), SIRT5OE sham (n = 4) and SIRT5OE TAC (n = 10)]. Two-way ANOVA interaction term: p-value = 0.0012. (E) Representative images of heart sections stained with Picrosirius red for collagen. (F) Summary figure of effects of SIRT5 overexpression during pressure overload.