Table 1.

Echocardiogram measurements 4 weeks after surgery in WT, SIRT5 sham and TAC mice.

	WT sham (n = 16)	WT TAC (n = 12)	SIRT5OE sham (n = 11)	SIRT5OE TAC (n = 14)	Genotype Effect	TAC Effect	Interaction Effect
Age at Procedure (months)	5.32 ± 0.60	5.26 ± 0.50	5.88 ± 0.82	5.26 ± 0.46	0.6473	0.5728	0.6469
Heart rate (bpm)	504.75 ± 13.31	487.17 ± 19.47	502.26 ± 17.59	452.04 ± 14.58	0.250	0.041*	0.317
LV Mass/BW	3.86 ± 0.11	9.37 ± 0.56	4.01 ± 0.13	7.55 ± 0.32	0.012*	< 0.001*	0.003*
IVS thickness diastole (mm)	0.77 ± 0.02	1.18 ± 0.03	0.80 ± 0.03	1.15 ± 0.03	0.937	< 0.001*	0.217
IVS thickness systole (mm)	1.15 ± 0.04	1.47 ± 0.04	1.21 ± 0.04	1.47 ± 0.04	0.540	< 0.001*	0.433
LV diameter diastole (mm)	3.89 ± 0.05	4.61 ± 0.14	3.82 ± 0.10	4.11 ± 0.08	0.004*	< 0.001*	0.027*
LV diameter systole (mm)	2.86 ± 0.05	3.81 ± 0.15	2.72 ± 0.10	3.14 ± 0.09	< 0.001*	< 0.001*	0.007*
PW thickness diastole (mm)	0.72 ± 0.02	1.12 ± 0.04	0.78 ± 0.03	1.14 ± 0.04	0.208	< 0.001*	0.523
PW thickness systole (mm)	1.02 ± 0.04	1.35 ± 0.05	1.10 ± 0.04	1.47 ± 0.05	0.082+	< 0.001*	0.993
LV Volume diastole (uL)	65.76 ± 2.11	99.41 ± 7.53	63.33 ± 3.74	75.44 ± 3.51	0.004*	< 0.001*	0.018*
LV Volume systole (uL)	31.35 ± 1.39	63.99 ± 6.57	29.05 ± 2.65	39.86 ± 2.70	< 0.001*	< 0.001*	0.004*
Ejection Fraction (%)	0.52 ± 0.01	0.36 ± 0.02	0.55 ± 0.02	0.47 ± 0.02	0.002*	< 0.001*	0.036*
Fractional Shortening (%)	0.27 ± 0.01	0.18 ± 0.01	0.28 ± 0.02	0.24 ± 0.01	0.003*	< 0.001*	0.061+

Values listed as mean ± standard error of the mean (SEM). Statistical significance was determined using two-way ANOVA. Significance markers: (*) p < 0.05, ( +) p < 0.1