Skip to main content
. 2022 Jul 18;10:48. doi: 10.1038/s41413-022-00219-8

Table 1.

Systemic and local factors influencing osteocyte function

Stimuli (Systemic/Local) Features affected (Local) Factors released (Local/Systemic) Final outcome (Systemic/Local)

PTH

Estrogens

1,25(OH)2D3

Irisin

Calcitonin

Senescence

TGF-β1

Pi

pO2

Life-Span

Network formation

Secretome

Mechanotrasduction

Sclerostin, DKK1, FGF23, DMP1, Phex, MEPE, Sema 3A RANKL, OPG SASPs, TGF-β1 OCN

• Bone Remodeling Balance

• Matrix Mineralization

• Perilacunocanalicular Remodeling

• Errors correction in Ca2+/P homeostasis

• Energy metabolism

• Myogenesis

• Oxidative stress

Major systemic and local stimuli that influence osteocyte activity, the functions affected, the factors released upon exposure to the stimuli, and the impact on the system