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. 2022 Jul 18;13:4167. doi: 10.1038/s41467-022-31719-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Coxcomb diagrams showing the distribution of 17 SCCs in 6 subtypes, including (1) Classical squamous (ClSq), (2) Fatty acid metabolic (FaSq), (3) Basophils inflamed (BaSq), (4) Neutrophils inflamed (NeSq), (5) Eosinophils inflamed (EoSq), and (6) Immune hot (IhSq). b Proteome-based microenvironmental cell signatures and over-represented pathways in 6 subtypes. c Represented morphologies of SCCs with specific tumor microenvironment cell infiltrating in 4 subtypes (subtype 1, 4–6). Arrows depict the specific cell types. Basophils were not shown because they cannot be recognized by HE staining. Scale bar, 100 μm. d Haematoxylin and eosin (H&E) stained and PLIN1 immunohistochemistry (IHC) images showing one example of subtype 2 samples with suspected lipid droplets. e Drug targets in 6 subtypes (drug targets discussed in the text were in bold).