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. 2022 Mar 2;269(8):4195–4203. doi: 10.1007/s00415-022-11041-x

Table 1.

Association of environmental factors and AAO

Yes No p value
Tobacco
 n 2148 3375 NA
 Median AAO (IQR) 63.5 (56.1–69.1) 60.8 (53.7–66.7) < 0.0001
Coffee
 n 3993 1133 NA
 Median AAO (IQR) 61.9 (54.7–67.6) 59.4 (52.1–65.6) < 0.0001
Black tea
 n 1719 2449 NA
 Median AAO (IQR) 61.0 (54.1–66.7) 61.3 (53.5–67.2) 0.8228
Aspirin
 n 1003 1989 NA
 Median AAO (IQR) 64.0 (57.9–69.0) 59.1 (51.8–64.9) < 0.0001

Median AAO stratified by tobacco use, coffee consumption, black tea consumption and aspirin intake