Table 2.
Dementia incidence and outcomes after dementia
| Parkinson’s disease | Controls | |||
|---|---|---|---|---|
| No dementia | Dementia | No dementia | Dementia | |
| N = 104 | N = 97a | N = 214 | N = 46 | |
|
Dementia incidence (N/person-years = incidence rate/100 person-years (95% confidence interval)) | ||||
| All | 93/1250.5 = 7.4 (6.1–9.1) | 46/2226.0 = 2.1 (1.5–2.7) | ||
| Men | 52/706.4 = 7.4 (5.6–9.7) | 22/1399.4 = 1.6 (1.0–2.4) | ||
| Women | 41/548.4 = 7.5 (5.5–10.1) | 24/815.7 = 2.9 (2.0–4.4) | ||
| Age < 60 | 4/252.4 = 1.6 (0.6–4.2) | 0/265.4 = 0 (undefined) | ||
| Age 60–69 | 15/263.6 = 5.7 (3.4–9.4) | 1/327.8 = 0.3 (0.0–2.2) | ||
| Age 70–79 | 49/533.5 = 9.2 (6.9–12.1) | 20/1027.1 = 1.9 (1.3–3.0) | ||
| Age 80 + | 25/205.2 = 12.2 (8.2–18.0) | 25/605.8 = 4.1 (2.8–6.1) | ||
| Median age at dementia (IQR) | 80.4 (75.6–85.3) | 86.8 (83.3–89.4) | ||
|
Median time in years from baseline to dementia (95% CI) |
8.5 (7.0–11.0) | Not reached | ||
| Number dead (%) | 69 (66) | 67 (69) | 105 (49) | 30 (65) |
| Median age at death (IQR) | 81.1 (76.1–86.5) | 84.3 (79.2–88.0) | 87.1 (81.8–90.3) | 90.1 (87.0–92.8) |
|
Median time in years from baseline to death (95% CI) |
7.3 (5.5–8.8) | 7.8 (7.0–8.8) | 12.5 (10.9–14.8) | 10.6 (8.5–12.9) |
|
Median time in years from dementia to death (95% CI) |
3.1 (2.3–3.6) | 3.1 (2.2–5.8) | ||
| Number institutionalized (%) | 13 (13) | 59 (61) | 24 (11) | 21 (46) |
| Median age at institutionalization (IQR) | 77.7 (72.1–83.5) | 81.2 (77.5–86.7) | 92.2 (87.8–94.1) | 88.5 (83.4–89.7) |
|
Median time in years from baseline to institutionalization (95% CI)b |
Not reached | 8.0 (6.5–9.0) | 15.6 (14.4-undefined) | 11.0 (8.9-undefined) |
|
Median time in years from dementia to institutionalization (95% CI)c |
2.7 (2.1–3.2) | 4.3 (1.7-undefined) | ||
All median times in this table were calculated from Kaplan–Meier probabilities
CI = confidence interval
a4 patients were excluded from survival analyses of dementia, because they developed dementia prior to baseline assessment
b1 patient and 2 controls were institutionalized before baseline
c20 patients and 4 controls developed dementia after time of institutionalization