Table 2.
Schizotypal characteristics between controls, and diagnosis groups, C9orf72 expansion status, and the presence of psychotic features
| Controls (n = 17) | bvFTD (n = 35) | ALS–FTD (n = 10) | ALS (n = 37) | C9 carriers (n = 14) | Non-carriers (n = 68) | Patients with psychosis (n = 25) | Patients without psychosis (n = 57) | pa | Post-hoc | |
|---|---|---|---|---|---|---|---|---|---|---|
| SPQ | ||||||||||
| Positive schizotypy | 1.2 (1.3) | 6.3 (7.1) | 9.8 (7.2) | 3.2 (2.7) | 8.9 (5.6) | 4.6 (5.8) | 10.4 (6.3) | 3.1 (4.1) | < .001 | bvFTD, ALS–FTD, ALS > Control |
| < .001 | ALS–FTD > ALS | |||||||||
| < .001 | C9, Noncarriers > Control | |||||||||
| < .001 | C9 > Noncarriers | |||||||||
| < .001 | With psychosis > Without psychosis, Control | |||||||||
| Negative schizotypy | 2.8 (2.3) | 9.7 (8.5) | 12.4 (8.8) | 5.8 (4.9) | 12.1 (8.2) | 7.5 (7.1) | 12.6 (8.6) | 6.4 (6.0) | < .001 | bvFTD, ALS–FTD > Control |
| < .001 | C9, Noncarriers > Control | |||||||||
| ALS–FTD > ALS | ||||||||||
| < .001 | With psychosis > Without psychosis, Control | |||||||||
| < .001 | Without psychosis > Control | |||||||||
| Disorganised thought disorder | 1.1 (1.7) | 4.0 (4.1) | 6.7 (4.4) | 2.4 (2.2) | 4.4 (2.5) | 3.4 (3.8) | 5.7 (4.1) | 2.7 (3.0) | < .001 | bvFTD, ALS–FTD, ALS > Control |
| ALS–FTD > ALS | ||||||||||
| .001 | C9, Noncarriers > Control | |||||||||
| < .001 | With psychosis > Without psychosis, Control |
Means (standard deviation). ap value for Kruskal–Wallis test statistics. Post hoc = Mann–Whitney U post hoc comparison results
bvFTD behavioral variant frontotemporal dementia, ALS–FTD amyotrophic lateral sclerosis–frontotemporal dementia, ALS amyotrophic lateral sclerosis, SPQ Schizotypal Personality Questionnaire