Fig. 6.

Metabolic enzymes with decreased K-acetylation in HCC tumors.A, metabolic enzymes with downregulated K-acetylation involved in glycolysis, TCA cycle, fatty acid metabolism, biosynthesis of amino acid, and valine, leucine, isoleucine degradation. B and C, the protein structures of GPI (PDB_1JLH) (B) and MDH2 (PDB_4WLF) (C). The differentially K-acetylated sites are marked in red. The images were generated in Pymol (version: 2.5.0). See also supplemental Fig. S4. GPI, glucose-6-phosphate isomerase; HCC, hepatocellular carcinoma.