Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jul 5;13:913901. doi: 10.3389/fimmu.2022.913901

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Jiang, Zhang, Hu, Shang, Ming, Deng, Li, Ma, Liu and Zhou

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Proposed mechanisms of SP-D interference with OA chondrocyte inflammatory response and cartilage degradation. (A–C) The spatial filling model illustrated that SP-D was fully embedded in the inhibitory pocket of TLR4/MD-2 homodimer complex. The surface of SP-D binds to TLR4/MD-2 homodimer complex with average generalized born score of -25.03 kcal/mol and average poisson-boltzmann of -46.87 kcal/mol. (D) SP-D as a modulator of inflammatory response via inhibition of TLR4-mediated NF-κB activation and PI3K/Akt pathways.