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. 2022 Jul 5;13:913901. doi: 10.3389/fimmu.2022.913901

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Copyright © 2022 Jiang, Zhang, Hu, Shang, Ming, Deng, Li, Ma, Liu and Zhou

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RAAV-mediated SP-D gene was transferred into the rat knee joints. (A) Rats were injected intra-articularly with rAAV encoding SP-D-specific shRNA for 10 consecutive days and sacrificed at the fourth week of the first injection. H&E staining and immunohistochemical staining of SP-D, CD68, F4/80, and TLR4 protein levels in cartilage were assessed following rAAV-GFP or rAAV-SP-D shRNA injection into the rat knee joints. The ratios of immunoreactive cells of SP-D (B), CD68 (C), F4/80 (D), and TLR4 (E) were analyzed. Data were expressed as mean ± SEM (n = 5). ^**P < 0.01 and ^***P < 0.001 vs. rAAV-GFP group.