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The rescue of cartilage degeneration by SP-D in rat OA model. (A) H&E, Safranin O and toluidine blue O-stained tissue histology in rat articular cartilage at 10 weeks post-surgery. (B) The modified Mankin scores were assigned to tissue samples. Data were expressed as mean ± SEM (n = 5). ***P < 0.001 vs. the sham-operated group; ##P < 0.01 and ###P < 0.001 vs. the OA-induction group; &P < 0.05 vs. OA + rhSP-D group; @@P < 0.01. vs. OA + TAK-242 group.
