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. 2022 Jul 5;13:913901. doi: 10.3389/fimmu.2022.913901

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Copyright © 2022 Jiang, Zhang, Hu, Shang, Ming, Deng, Li, Ma, Liu and Zhou

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SP-D modulated TLR4-mediated Akt signaling in vivo. (A) Immunofluorescence with an antibody to p-Akt in articular cartilage from the ACLT + MMx -induced OA rats with rhSP-D and TAK-242 treatment at 10 weeks post-surgery. (B) The ratios of immunoreactive cells were quantified in articular cartilage according to immunofluorescence. Data were expressed as mean ± SEM (n = 5). ^***P < 0.001 vs. the sham-operated group; ^###P < 0.001 vs. the OA-induction group; ^&&&P < 0.001 vs. OA + rhSP-D group; ^@@@P < 0.001 vs. OA + TAK-242 group.