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. 2022 Jul 5;13:913901. doi: 10.3389/fimmu.2022.913901

Figure 7.

Figure 7

SP-D regulated TLR4-mediated NF-κB pathway in vivo. (A) Immunofluorescence with an antibody to p-p65 in articular cartilage from the ACLT + MMx-induced OA rats with rhSP-D and TAK-242 treatment at 10 weeks post-surgery. (B) The ratios of immunoreactive cells were quantified in articular cartilage according to immunofluorescence. Data were expressed as mean ± SEM (n = 5). ***P < 0.001 vs. the sham-operated group; ###P < 0.001 vs. the OA-induction group; &&P < 0.01 vs. OA + rhSP-D group; @@@P < 0.001 vs. OA + TAK-242 group.