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. 2022 Jul 5;13:913901. doi: 10.3389/fimmu.2022.913901

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Copyright © 2022 Jiang, Zhang, Hu, Shang, Ming, Deng, Li, Ma, Liu and Zhou

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of SP-D on inflammation and ECM by suppressing TLR4-mediated PI3k/Akt and NF-κB signalings in chondrocytes. (A–C) The protein expression of Collagen II, MMP-13, NLRP3, p-PI3K, PI3K, p-Akt, Akt, MD-2, TLR4, p-p65, and p65 were assessed via western blotting with GAPDH as a loading control. (D–K) The ratios of Collagen II, MMP-13, NLRP3, MD-2, and TLR4 to GAPDH, and p-PI3K/PI3K, p-Akt/Akt, p-p65/p65 were analyzed. Data were expressed as mean ± SEM (n = 3). ^***P < 0.001 vs. the control group; ^##P < 0.01 and ^###P < 0.001 vs. the LPS group; ^&P < 0.05, ^&&P < 0.01 and ^&&&P < 0.001 vs. the LPS + rhSP-D group. OP-SP-D, SP-D overexpressing plasmid; OP-NC, Negative control plasmid.