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. 2022 Jul 5;9:695004. doi: 10.3389/fcvm.2022.695004

FIGURE 1.

FIGURE 1

Paeonol improved the cardiac function and ameliorated the cardiac damage of CHF rats. (A–E) The parameters underlying the cardiac function of the rats, including LVSP (A), LVEDP (B), +dp/dtmax (C), –dp/dtmax (D), and HR (E), were detected using RM6240 series multichannel physiological signal acquisition apparatus. (F–K) The concentration of several specific markers related to the myocardial damage in the rats, including BNP (F), LDH (G), RE (H), Ang II (I), ALD (J), and ET-1 (K), were evaluated using a Synergy H1 Hybrid Multi-Mode Reader. ∧∧P < 0.01, ∧∧∧P < 0.001, vs. Sham; *P < 0.05, **P < 0.01, ***P < 0.001, vs. DOX. DOX, doxorubicin; LVSP, left ventricular systolic pressure; LVEDP, left ventricle end diastolic pressure; +dp/dtmax, +left ventricle dp/dtmax; –dp/dtmax, –left ventricle dp/dtmax; HR, heart rate; BNP, brain natriuretic peptide; LDH, lactate dehydrogenase; RE, renin; Ang II, angiotensin II; ALD, aldosterone; ET-1, endothelin 1.