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. 2022 Jul 5;9:695004. doi: 10.3389/fcvm.2022.695004

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Copyright © 2022 Chen, Liu, Cao, Hu, Wang, Wu, Liu and Yiu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Paeonol ameliorated histopathological injury, suppressed apoptosis, and downregulated the miR-21-5p expression in the myocardium of CHF rats. (A) The myocardial histopathology of the rats was detected by hematoxylin–eosin staining (magnification of ×200). (B) The myocardial apoptosis of the rats was detected by TUNEL staining (Magnification: ×200). (C,D) The levels of Bcl-2, Bax, caspase-3, C-caspase-3, and Cyt C in the myocardium of rats were detected by Western blot. GAPDH was used as an internal control. (E) The expression of miR-21-5p in the myocardium of rats was detected by RT-qPCR, with U6 serving as an internal control. ^∧P < 0.05, ^∧∧P < 0.01, ^∧∧∧P < 0.001, vs. Sham; *P < 0.05, **P < 0.01, ***P < 0.001 vs. DOX. DOX, doxorubicin.