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. 2022 Jul 5;9:695004. doi: 10.3389/fcvm.2022.695004

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Copyright © 2022 Chen, Liu, Cao, Hu, Wang, Wu, Liu and Yiu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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miR-21-5p mimic counteracted the effects of paeonol on the MMP and ROS of the DOX-induced cardiomyocytes. (A,B) The ROS level in the DOX-induced H9c2 cells treated with miR-21-5p mimic or Paeonol-M was observed by H2DCFDA staining. (C,D) The MMP in the DOX-induced H9c2 cells treated with miR-21-5p mimic or Paeonol-M was determined by TMRM staining. **P < 0.01, ***P < 0.001 vs. DOX + MC;^###P < 0.001, vs. DOX + M;^∧∧∧P < 0.001 vs. DOX + Paeonol-M + MC. DOX, doxorubicin; MMP, mitochondrial membrane potential; ROS, reactive oxygen species; M, miR-21-5p mimic; MC, mimic control.