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. 2022 Jul 5;10:854845. doi: 10.3389/fbioe.2022.854845

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Copyright © 2022 Pipino, Bernabé-García, Cappellacci, Stelling-Férez, Di Tomo, Santalucia, Navalón, Pandolfi and Nicolás.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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AM reduces the expression of genes involved in inflammation. Gene expression analysis of VCAM-1 (A), ICAM-1 (B), CCL2 (C), and SELE (D), from C- and GD-HUVECs untreated and after TNF-α stimulation of cells that had been pretreated or not with AM for 24 h. Quantitative data in the histograms (A–D) show the mRNA relative expression (target gene expression normalized with GAPDH expression using the 2-ΔΔCt method). Each measurement is defined as the mean ± SD using three different strains for C-HUVECs and three different strains for GD-HUVECs (n = 3). ANOVA and Tukey’s multiple comparison test: *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001.