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. 2022 Jul 5;9:859014. doi: 10.3389/fcvm.2022.859014

Figure 1.

Figure 1

Effect of BNP on atrial inotropy and lusitropy after adrenergic stimulation. Example traces of time-dependent analysis of BNP (n = 20 strips) are shown in (A), with the corresponding data on the effect of BNP treatment on atrial systolic force (B), and end-diastolic tension generation (C) after 70 min. The slope of end-diastolic tension over time is shown in (D). The effects of a frequency-variation protocol [example traces in (E), n = 40 strips] on systolic force at different stimulation frequencies are shown in (F,G). Correlation of patient plasma NTproBNP and relative force increase after ISO treatment (values from n = 19 patients with available NTproBNP) is shown in (H). Data are shown as mean ± SEM; each data point represents one muscle strip. In (H), each point represents the mean developed systolic force per patient. ISO, isoproterenol; BNP, brain natriuretic peptide.