Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jul 5;9:859014. doi: 10.3389/fcvm.2022.859014

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Primessnig, Deißler, Wakula, Tran, Hohendanner, von Lewinski, Blaschke, Knosalla, Falk, Pieske, Grubitzsch and Heinzel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Effect of Sac/Val on atrial inotropy and lusitropy after adrenergic stimulation. Example traces of a “frequency-variation protocol” in Sac-treated muscle strips (n = 15 strips) are shown in (A), with its effects on developed force during different frequencies shown in (B,C). Examples traces of a frequency-variation protocol in Sac/Val treated muscle strips (n = 24 strips) are shown in (D), with the corresponding effects on developed force in (E,F). The effects of Sac/Val on end-diastolic tension are shown as per stimulation frequency (G) and as the diastolic tension slope derived from linear regression (H). Data are shown as mean ± SEM; each data point represents one muscle strip. ISO, isoproterenol, Sac: Sacubitrilat; Val: valsartan; Veh: vehicle (DMSO).