. 2022 Apr 25;43(12):3809–3823. doi: 10.1002/hbm.25885

TABLE 2.

Statistical results for linear mixed effects models with significant effects of group that survived FDR correction on DTI metrics of examined white matter tracts

Predictors	Arcuate fasciculus MD				Anterior thalamic radiation MD
	Estimates	95% CI	Statistic	p*	Estimates	95% CI	Statistic	p*
Intercept	*0.74*	*0.73 to 0.74*	*371.90*	*<.001*	*0.76*	*0.76 to 0.76*	*443.88*	*<.001*
Group (OI—mTBI)	2.46e−3	‐3.71e−2 to 0.01	0.79	.432	‐1.74e−3	−0.01 to 3.53e−3	−0.65	.517
Time (days) post‐injury	*−0.15*	*−0.22 to −0.08*	*−4.38*	*<.001*	*−0.12*	*−0.19 to −0.06*	*−3.58*	*<.001*
Time²	−0.08	−0.15 to −0.01	−2.16	.030	−0.02	−0.09 to 0.05	−0.48	.629
Age at injury (centered)	*−0.01*	*−0.01 to −0.01*	*−9.83*	*<.001*	*−3.92e−3*	*−0.01 to −1.92e−3*	*−3.83*	*<.001*
Sex (female—male)	*0.01*	*0.01 to 0.02*	*4.42*	*<.001*	*0.01*	*4.19e−3 to 0.01*	*3.92*	*<.001*
Hemisphere (left—right)	*3.41e−3*	*2.15e−3 to 7.83e−3*	*5.31*	*<.001*	*0.02*	*0.01 to 0.02*	*25.59*	*<.001*
Group × time	0.12	0.03 to 0.22	2.56	.011	*0.15*	*0.06 to 0.25*	*3.15*	*.002*
Group × time²	*0.16*	*0.05 to 0.28*	*2.86*	*.004*	*0.15*	*0.04 to 0.26*	*2.67*	*.008*
Group × age	3.59e−3	−6.50e−4 to 0.01	1.66	.097	1.70e−3	−1.91e−3 to 0.01	0.93	.354
Group × sex	−5.40e−4	−0.01 to 0.01	−0.13	.898	−4.10e−4	−0.01 to 0.01	−0.12	.908
Time × age	3.92e−3	−0.03 to 0.04	0.21	.833	−0.04	−0.07 to −5.10e−4	−1.99	.047
Time² × age	−1.76e−3	−0.04 to 0.04	−0.08	.933	−0.02	−0.06 to 0.03	−0.76	.447
Time × sex	0.12	0.04 to 0.20	2.88	.004	*0.12*	*0.04 to 0.20*	*2.84*	*.005*
Time² × sex	0.07	−0.02 to 0.15	1.51	.130	0.01	−0.08 to 0.10	0.28	.783
Group × time × age	0.03	−0.04 to 0.09	0.86	.390	0.03	−0.03 to 0.09	0.97	.333
Group × time² × age	−0.01	−0.08 to 0.07	−0.13	.895	−0.06	−0.14 to 0.01	−1.71	.087
Group × time × sex	−0.08	−0.21 to 0.05	−1.22	.224	−0.12	−0.25 to 0.01	−1.88	.061
Group × time² × sex	−0.20	−0.35 to −0.05	−2.55	.011	−0.12	−0.27 to 0.02	−1.66	.096
Random effects
ICC	0.76				0.69
Observations	1594				1784
Marginal R ²/conditional R ²	0.193/0.803				0.157/0.735

Note: Effect sizes, that is, Cohen's d (95% CI), for the pairwise comparisons between the mTBI and OI groups are reported in Table S2. *Uncorrected p‐values reported. Bolded = uncorrected p <.05; bolded/italic = FDR corrected p <.05.

Abbreviations: CI, confidence interval; mTBI, mild traumatic brain injury; OI, orthopedic injury.