. 2022 Apr 25;43(12):3809–3823. doi: 10.1002/hbm.25885

TABLE 4.

Statistical results for linear mixed effects models with significant effects of symptom groups based on parent report that survived FDR correction on DTI metrics of examined white matter tracts

	Superior longitudinal fasciculus FA				Arcuate fasciculus MD				Superior longitudinal fasciculus MD				Anterior thalamic radiations MD
Predictors	Estimates	CI	Statistic	p	Estimates	CI	Statistic	p	Estimates	CI	Statistic	p	Estimates	CI	Statistic	p
(Intercept)	*0.44*	0.43 to 0.45	71.62	<.001	0.74	0.73 to 0.75	158.12	<.001	0.74	0.73 to 0.76	135.52	<.001	0.77	0.76 to 0.77	193.10	< .001
Group ^a	‐	‐	*5.73*	.003	‐	‐	0.32	.730	‐	‐	0.21	.813	‐	‐	1.33	.265
Time (days) post‐injury	0.11	−0.25 to 0.46	0.59	.557	−0.07	−0.22 to 0.08	−0.96	.337	0.02	−0.18 to 0.22	0.18	.854	−0.06	−0.21 to 0.09	−0.80	.423
Time²	0.04	−0.29 to 0.38	0.25	.799	−0.02	−0.16 to 0.13	−0.25	.806	0.03	−0.17 to 0.23	0.27	.790	0.09	−0.05 to 0.24	1.25	.210
Age (centered)	0. 02	0.01 to 0.03	4.95	< .001	*−0.01*	−0.02 to −0.01	−4.54	<.001	−0.02	−0.02 to −0.01	−4.58	<.001	−0.01	−0.01 to −2.73e−3	−3.01	.003
Sex (female—male)	−2.670e−3	−0.02 to 0.01	−0.32	.746	0.01	−3.92e−3 to 0.02	1.34	.180	3.06e−3	−0.01 to 0.02	0.41	.681	−2.60e−4	−0.01 to 0.01	−0.05	.961
Hemisphere (left—right)	*0.03*	0.02 to 0.03	16.70	< .001	*3.40e−03*	2.06e−3 to 4.75e−3	4.95	<.001	0.01	4.58e−3 to 0.01	7.32	<.001	0.01	0.01 to 0.02	23.64	< .001
Group × (time + time²) ^b	‐	‐	0.34	.851	‐	‐	*3.12*	*.014*	‐	‐	*3.63*	.006	‐	‐	*3.83*	.004
Group × age ^a	‐	‐	3.92	.020	‐	‐	1.52	.221	‐	‐	3.96	.020	‐	‐	1.85	.159
Group × sex ^a	‐	‐	0.64	.529	‐	‐	1.11	.895	‐	‐	0.53	.592	‐	‐	1.24	.290
Time × age	0.13	−0.11 to 0.37	1.06	.287	−0.05	−0.16 to 0.05	−0.95	.343	−0.09	−0.23 to 0.05	−1.26	.206	−0.09	−0.19 to 0.01	−1.85	.064
Time² × age	0.09	−0.14 to 0.32	0.79	.427	4.07e−03	−0.10 to 0.10	0.08	.936	−0.01	−0.14 to 0.13	−0.10	.921	−0.06	−0.16 to 0.04	−1.16	.248
Time × sex	−0.14	−0.59 to 0.32	−0.59	.554	0.08	−0.11 to 0.27	0.84	.402	0.02	−0.23 to 0.28	0.18	.857	0.18	−3.65e−3 to 0.37	1.92	.055
Time² × sex	0.01	−0.45 to 0.47	0.06	.952	−0.12	−0.32 to 0.07	−1.24	.215	−0.16	−0.43 to 0.12	−1.12	.262	−0.13	−0.33 to 0.06	−1.33	.185
Group × (time + time²) × age ^b	‐	‐	0.33	.861	‐	‐	0.65	.627	‐	‐	0.55	.702	‐	‐	1.70	.148
Group × (time + time²) × sex ^b	‐	‐	0.65	.630	‐	‐	1.88	.112	‐	‐	0.49	.743	‐	‐	2.90	.021
Random effects
ICC	0.35				0.76				0.68				0.68
Observations	1566				1397				1566				1570
Marginal R ²/conditional R ²	0.179/0.468				0.179/0.801				0.149/0.728				0.158/0.732

Note: Effect sizes, that is, Cohen's d (95% CI), for the pairwise comparisons between the symptoms groups are reported in Table S3. *Uncorrected p‐values reported. Bolded = uncorrected p <.05; bolded/italic = FDR corrected p < .05.

^{^a}

df = 2.

^{^b}

df = 4.