TABLE 3.
Baseline characteristics stratified by SIPS.
| Variables | SIPS group (n = 1767) | P-value | ||
|
|
||||
| Low risk (n = 617) | Medium risk (n = 562) | High risk (n = 588) | ||
| Gender (%) | 0.001 | |||
| Male | 379 (61.4) | 369 (65.7) | 422 (71.8) | |
| Female | 238 (38.6) | 193 (34.3) | 166 (28.2) | |
| Age [mean (SD)] | 70.09 (5.26) | 71.25 (5.57) | 71.63 (5.55) | <0.001 |
| Age, > 70 years (%) | 213 (34.5) | 259 (46.1) | 289 (49.1) | <0.001 |
| BMI [mean (SD)] | 23.64 (3.18) | 22.17 (3.59) | 20.90 (3.25) | <0.001 |
| BMI, kg/m2 (%) | <0.001 | |||
| <18.5 | 24 (3.9) | 94 (16.7) | 142 (24.1) | |
| 18.5-23.9 | 325 (52.7) | 294 (52.3) | 344 (58.5) | |
| 24-27.9 | 218 (35.3) | 141 (25.1) | 88 (15.0) | |
| ≥ 28 | 50 (8.1) | 33 (5.9) | 14 (2.4) | |
| Smoking, yes (%) | 291 (47.2) | 290 (51.6) | 336 (57.1) | 0.002 |
| Alcohol, yes (%) | 131 (21.2) | 143 (25.4) | 153 (26.0) | 0.105 |
| Tumor types (%) | <0.001 | |||
| Lung cancer | 221 (35.8) | 205 (36.5) | 224 (38.1) | |
| Gastric cancer | 84 (13.6) | 88 (15.7) | 87 (14.8) | |
| Esophageal cancer | 31 (5.0) | 60 (10.7) | 48 (8.2) | |
| Colorectal cancer | 133 (21.6) | 95 (16.9) | 82 (13.9) | |
| Other digestive cancers | 38 (6.2) | 42 (7.5) | 58 (9.9) | |
| Breast cancer | 46 (7.5) | 16 (2.8) | 9 (1.5) | |
| Female reproductive cancer | 7 (1.1) | 10 (1.8) | 13 (2.2) | |
| Urological cancer | 30 (4.9) | 26 (4.6) | 31 (5.3) | |
| Nasopharyngeal cancer | 9 (1.5) | 8 (1.4) | 7 (1.2) | |
| Other cancer | 18 (2.9) | 12 (2.1) | 29 (4.9) | |
| Tumor stage (%) | <0.001 | |||
| I | 62 (10.0) | 41 (7.3) | 26 (4.4) | |
| II | 135 (21.9) | 86 (15.3) | 69 (11.7) | |
| III | 208 (33.7) | 143 (25.4) | 128 (21.8) | |
| IV | 212 (34.4) | 292 (52.0) | 365 (62.1) | |
| Surgery, yes (%) | 324 (52.5) | 235 (41.8) | 203 (34.5) | <0.001 |
| Radiotherapy, yes (%) | 38 (6.2) | 55 (9.8) | 61 (10.4) | 0.019 |
| Chemotherapy, yes (%) | 350 (56.7) | 311 (55.3) | 289 (49.1) | 0.021 |
| Immunotherapy, yes, (%) | 40 (6.5) | 22 (3.9) | 12 (2.0) | 0.001 |
| PGSGA [mean (SD)] | <0.001 | |||
| PGSGA (%) | 284 (46.0) | 172 (30.6) | 80 (13.6) | |
| Well nourished | 333 (54.0) | 390 (69.4) | 508 (86.4) | |
| Malnourished | 5.17 (3.76) | 7.14 (4.90) | 9.78 (5.21) | <0.001 |
| Nutritional intervention, yes (%) | 106 (17.2) | 123 (21.9) | 171 (29.1) | <0.001 |
| EORTCQLQ-C30 [mean (SD)] | 46.84 (9.95) | 50.48 (11.54) | 54.36 (12.82) | <0.001 |
| KPS [mean (SD)] | 87.23 (9.73) | 82.81 (13.68) | 76.85 (16.58) | <0.001 |
| KPS, < 60 (%) | 13 (2.1) | 51 (9.1) | 105 (17.9) | <0.001 |
SIPS: systemic inflammation prognostic score; SD: standard deviation; IQR: interquartile range; BMI: body mass index; ECOG PS: eastern cooperative oncology group performance status; KPS: karnofsky performance status; PGSGA: patient-generated subjective global assessment; EORTC QLQ-C30: The European Organization for Research and Treatment of Cancer (EORTC), Quality of Life Questionnaire-Core 30 (QLQ-C30).