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Summary of results.
| Virus | Cell type | Multiple-step growth curve | Thermal sensitivity (viral titer; 35°C/37°C/39°C) | Thermal stability (viral titer; 29°C/37°C/39°C) |
|---|---|---|---|---|
| rg-NS5-T7812G (G81G) | BHK-21 | ↑ | ↑/ns/↓ | ↑/ns/↑ |
| Vero | ↑ | ↑/↑/ns | ||
| Huh-7 | ns | ns/ns/ns | ||
| rg-NS5-C9420A (A617A) | BHK-21 | ns | ↑/ns/↓ | ns/ns/ns |
| Vero | ↑ | ↑/↑/↓ | ||
| Huh-7 | ns | ns/ns/ns |
↑, significantly higher than WT;
↓, significantly lower than WT; and
ns, no significant difference compared to WT.
