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. 2022 Jul 5;13:923869. doi: 10.3389/fimmu.2022.923869

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Copyright © 2022 Broens, van der Laken, Zwezerijnen, Nossent, Meijboom, Spierings, de Vries-Bouwstra, van Laar and Voskuyl

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pulmonary ¹⁸F-FDG positron emission tomography and high resolution computed tomography in patients with early severe diffuse cutaneous systemic sclerosis. (A) No visual uptake of ¹⁸F-FDG was observed in a patient with systemic sclerosis without interstitial lung disease. (B) Increased uptake of ¹⁸F-FDG in the lungs of a patient with systemic sclerosis associated interstitial lung disease is indicated by the arrows. (C) Repeated ¹⁸F-FDG positron emission tomography in the same patient, who had severe progression of interstitial lung disease after 3 months of cyclophosphamide pulse treatment. Higher uptake of ¹⁸F-FDG was seen at the follow-up scan when compared to baseline.