Table 2.

Summary of Unadjusted Bivariate Associations by Level of Current Tobacco and Alcohol Use (n = 15,947, Weighted N = 61,482,491).

Variable	Alcohol, Cigarette, and E-cigarette	Cigarette and E-cigarette	E-cigarette and Alcohol	Cigarette and Alcohol	E-cigarette Only	Cigarette Only	Alcohol Only
	OR (95% CI)	OR (95% CI)	OR (95% CI)	OR (95% CI)	OR (95% CI)	OR (95% CI)	OR (95% CI)
Internalizing Severity
Low	Reference	Reference	Reference	Reference	Reference	Reference	Reference
Moderate	1.71 (1.14–2.56)	1.50 (0.96–2.36)	1.36 (0.89–2.08)	1.79 (1.52–2.11)	1.12 (0.71–1.77)	1.37 (1.10–1.71)	1.66 (1.36–2.01)
High	3.42 (2.48–4.72)	2.24 (1.63–3.08)	2.20 (1.57–3.09)	2.28 (1.97–2.65)	1.30 (0.89–1.88)	1.69 (1.42–2.02)	1.42 (1.20–1.69)
Externalizing Severity
Low	Reference	Reference	Reference	Reference	Reference	Reference	Reference
Moderate	2.32 (1.59–3.39)	1.67 (1.15–2.42)	2.84 (1.91–4.23)	2.00 (1.68–2.38)	1.01 (0.67–1.52)	1.21 (1.01–1.43)	2.04 (1.70–2.44)
High	4.56 (3.31–6.30)	2.22 (1.61–3.05)	4.23 (2.84–6.29)	2.58 (2.19–3.03)	1.31 (0.89–1.94)	1.31 (1.11–1.55)	2.29 (1.91–2.76)
Nicotine Dependence
	1.05 (1.05–1.06)	1.08 (1.07–1.08)	1.00 (0.99–1.01)	1.05 (1.04–1.05)	1.00 (0.99–1.01)	1.06 (1.06–1.07)	0.97 (0.96–0.97)
Sex
Male	Reference	Reference	Reference	Reference	Reference	Reference	Reference
Female	1.24 (0.98–1.56)	1.74 (1.35–2.25)	1.26 (0.94–1.69)	1.21 (1.06–1.38)	1.99 (1.45–2.74)	1.65 (1.43–1.90)	0.71 (0.61–0.84)
Age
18–24 years old	Reference	Reference	Reference	Reference	Reference	Reference	Reference
25–34 years old	1.75 (1.37–2.25)	3.62 (2.53–5.20)	1.69 (1.21–2.35)	2.42 (2.02–2.89)	1.86 (1.08–3.20)	2.53 (2.04–3.12)	1.40 (1.17–1.67)
35–44 years old	1.28 (0.87–1.88)	2.93 (2.00–4.31)	0.84 (0.55–1.30)	1.95 (1.57–2.42)	1.49 (0.89–2.51)	2.27 (1.81–2.86)	0.90 (0.72–1.12)
45–54 years old	0.57 (0.41–0.79)	1.78 (1.15–2.75)	0.69 (0.44–1.10)	1.55 (1.28–1.87)	2.01 (1.26–3.21)	2.25 (1.89–2.68)	0.76 (0.63–0.93)
55–64 years old	0.46 (0.32–0.66)	1.99 (1.31–3.02)	0.64 (0.38–1.07)	1.21 (0.98–1.49)	1.04 (0.60–1.80)	2.02 (1.64–2.49)	0.63 (0.48–0.83)
65 years or older	0.16 (0.07–0.35)	1.42 (0.70–2.88)	0.31 (0.14–0.66)	0.60 (0.47–0.76)	1.03 (0.51–2.11)	1.90 (1.47–2.47)	0.47 (0.36–0.61)
Race
White	Reference	Reference	Reference	Reference	Reference	Reference	Reference
Non-Hispanic Black	0.23 (0.16 0.35)	0.35 (0.23–0.55)	0.45 (0.27–0.73)	0.61 (0.51–0.73)	0.37 (0.20–0.67)	0.50 (0.42–0.60)	0.63 (0.51–0.77)
Non-Hispanic Other	0.70 (0.44–1.12)	0.60 (0.38–0.94)	0.98 (0.56–1.72)	0.72 (0.56–0.91)	1.00 (0.57–1.76)	0.66 (0.53–0.82)	0.81 (0.62–1.06)
Hispanic Multicultural	0.32 (0.23–0.46)	0.32 (0.20–0.52)	0.35 (0.22–0.57)	0.48 (0.40–0.57)	0.58 (0.40–0.86)	0.50 (0.41–0.61)	0.67 (0.53–0.83)
Education
Less than high school	Reference	Reference	Reference	Reference	Reference	Reference	Reference
GED/High school	2.30 (1.61–3.28)	1.15 (0.75–1.78)	2.22 (1.16–4.26)	1.50 (1.24–1.81)	1.51 (0.90–2.53)	0.96 (0.80–1.17)	1.74 (1.39–2.17)
Some college	4.79 (3.28–6.99)	1.72 (1.16–2.56)	4.75 (2.60–8.67)	2.13 (1.78–2.56)	2.31 (1.46–3.64)	0.96 (0.80–1.15)	3.58 (2.89–4.43)
Bachelor’s degree	4.91 (3.26–7.39)	1.68 (0.99–2.86)	5.04 (2.47–10.32)	2.34 (1.85–2.97)	1.86 (1.00–3.46)	0.65 (0.48–0.88)	7.16 (5.41–9.49)
Advanced degree	3.67 (1.98–6.82)	0.69 (0.28–1.69)	2.32 (0.62–8.63)	1.50 (1.07–2.10)	1.85 (0.75–4.56)	0.40 (0.27–0.59)	6.73 (4.80–9.44)
Income
<$10,000	Reference	Reference	Reference	Reference	Reference	Reference	Reference
$10,000–24,999	1.94 (1.42–2.64)	1.49 (1.05–2.12)	1.31 (0.82–2.09)	1.33 (1.09–1.62)	1.07 (0.62–1.83)	1.26 (1.03–1.54)	1.30 (1.07–1.59)
$25,000–49,000	2.59 (1.85–3.62)	1.41 (0.98–2.02)	2.00 (1.41–2.83)	1.63 (1.36–1.97)	1.21 (0.77–1.92)	1.08 (0.89–1.31)	1.66 (1.35–2.05)
$50,000–99,999	2.95 (2.01–4.32)	1.33 (0.86–2.05)	3.03 (2.06–4.46)	1.98 (1.58–2.48)	1.82 (1.07–3.08)	0.90 (0.71–1.14)	3.04 (2.42–3.82)
≥$100,000	2.88 (1.83–4.53)	1.06 (0.59–1.91)	3.37 (2.16–5.24)	1.72 (1.38–2.14)	1.33 (0.68–2.62)	0.53 (0.38–0.72)	5.07 (3.91–6.57)

Bolded values indicate estimate significant a p < 0.05

The “none” category is used in reference for the tobacco and alcohol use outcome.