Table 2.
Proportion of participants with genetic antibiotic resistance determinants by antibiotic class by treatment group at 8 weeks from enrollment
Azithromycin (N = 49) | Amoxicillin (N = 46) | Odds ratio (95% CI) | P value* | |
---|---|---|---|---|
Macrolides | 32 (65%) | 30 (65%) | 1.00 (0.43–2.34) | 0.99 |
Beta-lactams | 40 (82%) | 38 (83%) | 0.94 (0.33–2.68) | 0.99 |
Fluoroquinolones | 29 (59%) | 22 (48%) | 1.58 (0.70–3.56) | 0.56 |
Sulfonamides | 24 (49%) | 14 (30%) | 2.19 (0.95–5.09) | 0.52 |
Trimethoprim | 38 (78%) | 26 (78%) | 0.96 (0.36–2.53) | 0.99 |
Tetracyclines | 45 (92%) | 40 (87%) | 1.69 (0.44–6.41) | 0.77 |
Rifampin | 19 (39%) | 15 (33%) | 1.31 (0.56–3.04) | 0.77 |
Aminoglycosides | 31 (63%) | 23 (50%) | 1.72 (0.76–3.91) | 0.52 |
Metronidazole | 24 (49%) | 29 (63%) | 0.56 (0.25–1.28) | 0.52 |
Aminocoumarins | 10 (20%) | 4 (9%) | 2.69 (0.78–9.29) | 0.52 |
Bacitracin | 19 (39%) | 12 (26%) | 1.79 (0.75–4.30) | 0.52 |
Fosfomycins | 1 (2%) | 2 (4%) | 0.46 (0.04–5.23) | 0.77 |
Elfamycins | 34 (69%) | 27 (59%) | 1.60 (0.69–3.71) | 0.56 |
Lipopeptides | 2 (4%) | 1 (2%) | 1.91 (0.17–21.9) | 0.80 |
Phenicol | 8 (16%) | 7 (15%) | 1.09 (0.36–3.28) | 0.99 |
Glycopeptides | 0 | 0 | NA | NA |
Cationic peptides | 30 (61%) | 22 (48%) | 1.72 (0.76–3.89) | 0.52 |
False discovery rate-adjusted P value.