Table 1.

Patient characteristics and immunohistochemistry results.

	COP	Sarcoidosis	IPF
	n = 13	n = 13	n = 21
Patient characteristics
Age, years	57.7 ± 4.8	49.2 ± 3.8**	63.3 ± 1.7
Gender, Male/female	4/9	4/9	16/5
Cumulative OCS (mg)	739.2 ± 138.7	990.8 ± 214.1	895.5 ± 147.3
CXR	2.84 ± 0.22	2.54 ± 0.31	3.23 ± 0.18
Post-OCS CXR CFB	-0.31 ± 0.31*	-0.69 ± 0.32**	1.00 ± 0.27
FVC (L)	1.553 ± 0.138*	2.373 ± 0.234	1.713 ± 0.156
Post-OCS FVC (L) CFB	0.230 ± 0.074	0.368 ± 0.216*	-0.208 ± 0.085
FVC %pred	55.9 ± 4.2	73.2 ± 5.2	65.7 ± 4.6
Post-OCS FVC %pred CFB	7.9 ± 2.9	5.6 ± 6.1	-7.3 ± 6.2
Staining findings
Neutrophils/HPF	0.85 ± 0.23*	0.85 ± 0.19*	2.97± 0.74
%IL-17	46.5 ± 4.4*	46.7 ± 5.2*	63.0 ± 3.4
IL-17 OD	1.32± 0.04*	1.31 ± 0.05**	1.48 ± 0.04
%IL-17RA	47.3 ± 6.2	45.4 ± 5.2	59.2 ± 4.1
IL-17RA OD	1.44 ± 0.03	1.41 ± 0.03	1.44 ± 0.03
%GR-β	55.7 ± 3.8****	58.2 ± 3.7***	73.8 ± 1.0
GR-β OD	1.33 ± 0.02*	1.35 ± 0.05	1.44 ± 0.02
%GR-α	65.9 ± 3.4	58.8 ± 4.9	60.2 ± 3.4
GR-α OD	1.33 ± 0.01	1.33 ± 0.02	1.33 ± 0.01
%GR-β/%GR-α	0.88 ± 0.08**	1.04 ± 0.08	1.33 ± 0.09
GR-β OD/GR-α OD	1.00 ± 0.02*	1.01 ± 0.02	1.09 ± 0.02
%HDAC2	55.8 ± 7.0	52.2 ± 6.6	57.6 ± 3.0
HDAC2 OD	1.30 ± 0.05	1.29 ± 0.02	1.29 ± 0.04

Data are present as mean ± SEM. COP, cryptogenic organizing pneumonia; IPF, idiopathic pulmonary fibrosis; CXR, chest radiographic grading of the extent of disease; CFB, change from baseline; OCS, oral corticosteroids; cumulative OCS, cumulative prednisolone or equivalent within 3 continuous months; FVC, forced vital capacity; %pred, percent of predicted value; HPF, high power fields (magnification, x400); IL-17, interleukin-17; IL-17RA, interleukin-17 receptor A; GR, glucocorticoid receptor; HDAC2, histone deacetylase 2; OD, opacity density. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 versus IPF.