Table 2.
Correlations between IL-17 and staining findings (neutrophil counts, IL-17, GR-β, GR-α, GR-β/GR-α, HDAC2).
| %IL-17 | p value | IL-17 OD | p value | ||
|---|---|---|---|---|---|
| ILD | |||||
| Neutrophils/HPF | 0.26 | 0.0752 | Neutrophils/HPF | 0.35* | 0.0157 |
| %IL-17RA | 0.45** | 0.0017 | IL-17 OD | 0.02 | 0.9005 |
| %GR-β | 0.39** | 0.0065 | GR-β OD | 0.61**** | < 0.0001 |
| %GR-α | -0.00 | 0.9903 | GR-α OD | -0.08 | 0.5758 |
| %GR-β/%GR-α | 0.29 | 0.0510 | GR-β OD/GR-α OD | 0.64**** | < 0.0001 |
| %HDAC2 | 0.00 | 0.9858 | HDAC2 OD | -0.09 | 0.5455 |
| IPF | |||||
| Neutrophils/HPF | 0.12 | 0.6160 | Neutrophils/HPF | 0.17 | 0.45 |
| %IL-17RA | 0.63** | 0.0023 | IL-17 OD | -0.27 | 0.2294 |
| %GR-β | 0.12 | 0.6080 | GR-β OD | -0.03 | 0.8933 |
| %GR-α | 0.28 | 0.2235 | GR-α OD | -0.5948** | 0.0045 |
| %GR-β/%GR-α | -0.18 | 0.4419 | GR-β OD/GR-α OD | 0.50* | 0.0206 |
| %HDAC2 | 0.18 | 0.4437 | HDAC2 OD | -0.16 | 0.4927 |
Correlations were determined by Spearman’s rank correlation. HPF, high power fields (magnification, x400); IL-17, interleukin-17; IL-17RA, interleukin-17 receptor A; GR, glucocorticoid receptor; HDAC2, histone deacetylase 2; OD, opacity density score; *p < 0.05; **p < 0.01; ****P < 0.0001.