Table 3.

Correlations between radiographic deterioration and staining findings (neutrophil counts, IL-17, GR-β, GR-α, GR-β/GR-α, HDAC2) in ILDs (COP, sarcoidosis and IPF in combination) and IPF subgroup.

Radiograph grading CFB after OCS	ILD	p value	IPF	p value
Neutrophils/HPF	0.12	0.3917	-0.10	0.67
%IL-17	0.39**	0.0067	0.44*	0.0462
IL-17 OD	0.48***	0.0006	0.72***	0.0003
%IL-17RA	0.02	0.9153	-0.2	0.4285
IL-17RA OD	0.02	0.8917	-0.08	0.7409
%GR-β	0.46**	0.0012	0.32	0.1528
GR-β OD	0.50***	0.0003	0.38	0.0904
%GR-α	0.05	0.7178	0.06	0.8041
GR-α OD	-0.20	0.1890	-0.63**	0.0021
%GR-β/%GR-α	0.23	0.1146	0.09	0.7135
GR-β OD/GR-α OD	0.57****	< 0.0001	0.84****	< 0.0001
%HDAC2	0.01	0.9547	-0.11	0.6426
HDAC2 OD	-0.25	0.0916	-0.28	0.2112

CXR, chest radiographic grading of the extent of disease; CFB, change from baseline; OCS, oral corticosteroids; ILD, interstitial lung diseases; COP, cryptogenic organizing pneumonia; IPF, idiopathic pulmonary fibrosis; HPF, high power fields (magnification, x400); IL-17, interleukin-17; IL-17RA, interleukin-17 receptor A; GR, glucocorticoid receptor; HDAC2, histone deacetylase 2; OD, opacity density score; *p < 0.05; **p < 0.01; ***p < 0.001; ****P < 0.0001 (Spearman’s rank correlation).