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In vitro fractional inhibitory concentration index from miltefosine and benznidazole on trypomastigotes and amastigotes stages of Trypanosoma cruzi (VD strain).
| Combination | Trypomastigotes | Amastigotes | ||||
|---|---|---|---|---|---|---|
| LC50 (µM) | FICI | ∑FICI | IC50 (µM) | FICI | ∑FICI | |
|
Fixed MLT +
Variable BZ |
2.845 | 0.17 | 0.46 | 0.34 | 0.38 | 0.71 |
|
Fixed BZ +
Variable MLT |
5.75 | 0.29 | 0.29 | 0.32 | ||
MLT, miltefosine. BZ, benznidazole. FICI, Fractional inhibitory concentration index.
