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. 2022 Jul 5;9:898871. doi: 10.3389/fmolb.2022.898871

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Copyright © 2022 Bleeker and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Model of how prostatitis promotes PCa. Multiple possible mechanisms have been proposed as illustrated in the diagram. Secreted cytokines may promote epithelial cell proliferation, basal-to-luminal cell differentiation, and epithelial barrier disruption. Inflammation-induced ROS production and Nkx3.1 down-regulation could also enhance DNA damage.