Table 4.
Differentially expressed chemokines and their chemotactic activities. TND = transcript not detected
| Chemokine | Key immune function | Differential expression in High dose | Differential expression in medium dose | Differential expression in Low dose | Chemotactic activity | |||
|---|---|---|---|---|---|---|---|---|
| log2 Fold Change | padj | log2 Fold Change | padj | log2 Fold Change | padj | |||
| CCL2 | Inflammatory monocyte trafficking | 4.03 | 3.76E-10 | 4.11 | 1.12E-08 | TND | TND | Classical monocyte, Natural killer cells |
| CCL4 | Macrophage and natural killer cell migration; T cell–dendritic cell interactions | 1.69 | 2.30E-02 | TND | TND | TND | TND | Nonclassical-Monocyte, Natural killer cells |
| CCL21 | T cell and dendritic cell homing to lymph node | TND | TND | −4.30 | 6.14E-04 | Neutrophils, CD8+ T cells, dendritic cells | ||
| CCL26 | Eosinophil and basophil migration | −5.28 | 2.51E-04 | −4.17 | 3.45E-03 | TND | TND | Th2 type T lymphocytes |
| CXCL2 | Neutrophil trafficking | 3.44 | 9.55E-06 | 2.68 | 1.70E-03 | TND | TND | Neutrophils, CD8+ T cells, monocytes/macrophage, natural killer cells |
| CXCL8 | Neutrophil trafficking | TND | TND | 2.42 | 1.22E-02 | TND | TND | Neutrophils, CD8+ effector T cells, monocytes/macrophage, natural killer cells |
| CXCL10 | Th1 response; Th1, CD8, NK trafficking | 1.62 | 8.29E-03 | 2.85 | 4.93E-05 | −2.56 | 1.61E-03 | CD8+ T cells, T helper cells (Th1), natural killer cells |
| CXCL13 | B cell and follicular helper (Tfh) cell positioning in lymph node | −2.52 | 2.35E-03 | −1.67 | 4.13E-02 | TND | TND | B cells |