Table 6.
Differentially expressed genes associated with autophagy. TND = transcript not detected
| Gene | Description | Differential expression in High dose | Differential expression in medium dose | Differential expression in Low dose | ||||
|---|---|---|---|---|---|---|---|---|
| log2 Fold Change | padj | log2 Fold Change | padj | log2 Fold Change | Padj | |||
| Autophagy-related Genes | ATG4C | Autophagy related 4C cysteine peptidase | −1.39 | 1.64E-02 | TND | TND | TND | TND |
| ATG4D | Autophagy related 4D cysteine peptidase | 1.10 | 4.64E-02 | TND | TND | TND | TND | |
| BNIP3 | BCL2 interacting protein 3 | 3.09 | 2.93E-09 | 2.53 | 1.72E-05 | TND | TND | |
| DCT | Dopachrome tautomerase | TND | TND | −1.94 | 4.41E-02 | TND | TND | |
| DRAM2 | DNA damage regulated autophagy modulator 2 | −2.39 | 9.44E-06 | −1.58 | 5.40E-03 | TND | TND | |
| EPG5 | Ectopic P-granules autophagy protein 5 homolog | TND | TND | −1.38 | 2.98E-02 | TND | TND | |
| FXR2 | FMR1 autosomal homolog 2 | TND | TND | 1.01 | 1.50E-02 | TND | TND | |
| NBR1 | NBR1 autophagy cargo receptor | −1.25 | 1.41E-03 | TND | TND | TND | TND | |
| SOGA1 | Suppressor of glucose, autophagy associated 1 | 1.41 | 1.47E-03 | TND | TND | TND | TND | |
| SSNA1 | SS nuclear autoantigen 1 | 1.23 | 2.04E-02 | 1.13 | 3.81E-02 | TND | TND | |
| FUNDC1 | FUN14 domain containing 1 | TND | TND | TND | TND | −0.96 | 3.69E-02 | |
| Autophagy and cell death regulating genes | GAS2L2 | Growth arrest-specific 2 like 2 | 4.93 | 1.26E-06 | TND | TND | TND | TND |
| GAS2L1 | Growth arrest specific 2 like 1 | 1.31 | 4.10E-02 | 1.39 | 2.98E-02 | TND | TND | |
| GAS2L3 | Growth arrest specific 2 like 3 | TND | TND | −2.32 | 2.45E-02 | TND | TND | |
| GAS7 | Growth arrest specific 7 | 1.86 | 5.02E-05 | TND | TND | TND | TND | |
| GAS8 | Growth arrest specific 8 | 3.74 | 2.60E-15 | 1.52 | 4.38E-03 | TND | TND | |
| MAD1L1 | Mitotic arrest deficient 1 like 1 | 3.30 | 2.53E-08 | TND | TND | TND | TND | |
| MAD1L2 | Mitotic arrest deficient 1 like 2 | 1.64 | 9.99E-03 | TND | TND | TND | TND | |
| GADD45G | Growth arrest and DNA damage inducible gamma | 2.25 | 1.39E-02 | 2.11 | 3.35E-02 | TND | TND | |
| GADD45B | Growth arrest and DNA damage inducible beta | 1.73 | 1.33E-02 | 2.00 | 8.46E-03 | TND | TND | |
| FAIM2 | Fas apoptotic inhibitory molecule 2 | TND | TND | 3.96 | 2.87E-03 | TND | TND | |
| NUPR1 | Nuclear protein 1, transcriptional regulator | 5.13 | 8.83E-14 | 5.73 | 6.21E-15 | TND | TND | |
| APAF1 | Apoptotic peptidase activating factor 1 | −1.49 | 6.29E-03 | TND | TND | TND | TND | |