Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jul 6;4(4):fcac176. doi: 10.1093/braincomms/fcac176

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022. Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Proteomic and transcriptomic analysis on D14 MNs. (A) Volcano plot displaying the proteomic changes in p97^R155H/+ MNs, log₂ (Fold Change) indicates the logarithm to the base 2 of fold change, n = 3. (B) Western blot showing increases in NES, MCM6, Filamin 1 and HSP47 are consistent with proteomic data. FC indicates the average fold change in (p97^R155H/+/isoWT). (C) Functional enrichment analysis on the proteins affected by p97^R155H/+. (D) Heatmap displaying the scaled abundance of DEPs related to cell cycle. (E) Volcano plot displaying the transcriptomic changes in p97^R155H/+ MNs. (F) Functional enrichment analysis on the DEGs identified from p97^R155H/+ MNs. (G) Heatmap representation of a comparison between RNA-seq and proteomics for cell cycle-related DEPs. Log2FC represents log₂ (Fold Change).