Table 2.

Longitudinal assessment of clinical outcomes

Control cohort (n = 35)					Study cohort (n = 36)		MDD (95% CI)	p value
	initial mean	follow-up mean	mean difference (95% CI)	p value	initial mean	follow-up mean	mean difference (95% CI)	p value
HADS anxiety	9.4	8.7	−0.7 (−2.1, 0.9)	0.40	9.0	8.2	−0.8 (−2.3, 0.6)	0.26	−0.1 (−2.3, 1.9)	0.85
HADS depression	5.2	5.1	−0.1 (−1.1, 0.8)	0.81	5.9	4.3	−1.6 (−2.5, –0.6)	0.001	−1.4 (−2.8, –0.1)	0.03
SIBDQ	43.4	46.1	+2.7 (−1.3, 6.8)	0.19	44.2	47.2	3.0 (−1.0, 7.0)	0.14	0.3 (−5.4, 6.0)	0.92
HBI	7.8	7.4	−0.4 (−2.4, 1.6)	0.67	7.1	5.5	−1.6 (−3.5, 0.4)	0.12	−1.1 (−4.0, 1.7)	0.43
SCCAI	5.1	4.6	−0.5 (−1.6, 0.6)	0.37	4.7	3.5	−1.2 (−2.3, –0.1)	0.04	−0.7 (−2.3, 0.9)	0.39

Bold numbers represent factors that were found to be significantly different during statistical comparison(s). The p values reported above were determined by comparing paired changes from the initial visit to the follow-up visit in each in category between the control and study cohorts (using a 2-sample t test). 95% CI, 95% confidence interval; MDD, mean difference of differences; HADS, Hospital Anxiety Depression Survey; SIBDQ, Short Inflammatory Bowel Disease Questionnaire; HBI, Harvey-Bradshaw Index; SCCAI, Short Clinical Colitis Activity Index.