Table 1.

ASTCT consensus grading for CRS

Clinical parameter	Grade 1	Grade 2	Grade 3	Grade 4
Fever	≥38 C	≥38 C	≥38 C	≥38 C
Hypotension	None	No Vasopressors utilized	Requiring a vasopressor with or without vasopressin	Requiring multiple vasopressors (excluding vasopressin)
Hypoxia	None	Low flow nasal cannula or blow by	High-flow nasal cannula, non-rebreather, facemask, Venturi mask	CPAP, BiPAP, mechanical ventilation

For stages 2+ patients must have a fever ≥38 C plus hypotension and/or hypoxia.

Patients may have other constitutional symptoms, but they do not affect the grade of CRS.

CPAP, continuous positive airway pressure; BiPAP, bilevel positive airway pressure.