Table 4.
Therapies ever applied, stratified according to pediatric or adult UC diagnosis
| Drugs ever applied | Pediatric UC diagnosis (<18 years old) (n = 184), n (%) | Adult UC diagnosis (≥18 years old) (n = 846), n (%) | p value |
|---|---|---|---|
| Oral 5-ASA | 170 (92.4) | 756 (89.4) | 0.216 |
| Topical 5-ASA | 86 (46.7) | 555 (65.6) | <0.001 |
| Any 5-ASA | 176 (95.7) | 815 (96.3) | 0.660 |
| Systemic steroids | 133 (72.3) | 624 (73.8) | 0.681 |
| Topical steroids (enema) | 51 (27.7) | 297 (35.1) | 0.055 |
| Any steroids | 147 (79.9) | 689 (81.4) | 0.626 |
| Azathioprine/mercaptopurine | 114 (62) | 520 (61.5) | 0.901 |
| Methotrexate | 29 (15.8) | 76 (9) | 0.006 |
| Tacrolimus and cyclosporine | 19 (10.3) | 88 (10.4) | 0.976 |
| Anti-TNF (IFX, ADA, and GOL) | 78 (42.4) | 298 (35.2) | 0.067 |
| Vedolizumab | 20 (10.9) | 93 (11) | 0.961 |
| Ustekinumab | 0 | 1 (0.1) | 0.641 |
| Tofacitinib | 1 (0.5) | 1 (0.1) | 0.235 |
ADA, adalimumab; IFX, infliximab; GOL, golimumab; 5-ASA, 5-aminosalicylates.