Table 6.

Hazard ratios (95% CI; p value) associated with decimal logarithm of diagnostic delay in Cox models for various complications (* adjustment is done for age and sex)

Outcome	Pediatric (crude HR)	Pediatric (adjusted* HR)	Adult (crude HR)	Adult (adjusted* HR)
Colectomy	0.038 (0.000–3.301;0.151)	0.043 (0.000–3.816; 0.169)	0.864 (0.489–1.527; 0.615)	0.869 (0.486–1.553; 0.636)
UC-related hospitalization	0.385 (0.134–1.108; 0.077)	0.379 (0.129–1.112; 0.077)	0.751 (0.466–1.213; 0.242)	0.774 (0.479–1.252; 0.297)
Colon dysplasia	NA	NA	3.119 (1.167–8.336; 0.023)	2.948 (1.158–7.504; 0.023)
Colorectal cancer	NA	NA	2.785 (0.613–12.657; 0.185)	2.480 (0.626–9.826; 0.196)
Any complication (colectomy, UC-related hospitalization, colon dysplasia, and cancer)	0.349 (0.120–1.009; 0.052)	0.344 (0.117–1.012; 0.053)	1.046 (0.727–1.503; 0.810)	1.072 (0.744–1.543; 0.710)
EIMs (any)	1.441 (0.935–2.222; 0.098)	1.455 (0.939–2.256; 0.094)	1.494 (1.290–1.729; <0.001)	1.491 (1.289–1.724; <0.001)
Oral erosions/ulcerations	1.213 (0.399–3.682; 0.733)	1.254 (0.407–3.868; 0.694)	1.216 (0.683–2.165; 0.506)	1.212 (0.679–2.162; 0.516)
Erythema nodosum	0.261 (0.018–3.717;0.321)	0.307 (0.027–3.508; 0.342)	2.089 (0.846–5.156; 0.110)	2.088 (0.847–5.146; 0.110)
Pyoderma gangrenosum	1.093 (0.127–9.442; 0.935)	1.116 (0.145–8.558; 0.916)	1.678 (0.204–13.782; 0.630)	1.434 (0.138–14.917; 0.763)
Arthritis/arthralgias	2.048 (1.158–3.622; 0.014)	1.989 (1.131–3.498; 0.017)	1.426 (1.210–1.682; <0.001)	1.420 (1.204–1.674; <0.001)
Primary sclerosing cholangitis	0.924 (0.378–2.257; 0.863)	0.914 (0.320–2.613; 0.866)	1.428 (0.860–2.370; 0.168)	1.542 (0.931–2.555; 0.093)
Uveitis/iritis	3.134 (0.268–36.682; 0.363)	3.563 (0.259–49.049; 0.342)	1.392 (0.785–2.470; 0.258)	1.392 (0.800–2.424; 0.242)
Ankylosing spondylitis/sacroiliitis	1.409 (0.180–11.051; 0.744)	1.478 (0.175–12.511;0.720)	3.404 (2.226–5.205; <0.001)	3.243 (2.154–4.882; <0.001)