Table 2.
Univariate and multivariate Cox regression analyses for OS in the whole cohort
| Variables | Univariate analyses |
Multivariate analyses (model 1) |
Multivariate analyses (model 2) |
|||
|---|---|---|---|---|---|---|
| HR (95%CI) | p value | HR (95% CI) | p value | HR (95% CI) | adjusted p value | |
| Age, per 1 year increase | 0.99 (0.98–1.01) | 0.196 | ||||
| Gender (refer to male) | 0.71 (0.40–1.26) | 0.241 | ||||
| Etiology (refer to HBV) | 0.32 (0.12–0.87) | 0.026 | 0.26 (0.10–0.71) | 0.009 | ||
| ECOG (refer to score of 0) | 1.20 (0.84–1.72) | 0.312 | ||||
| Tumor number (refer to single) | 1.25 (1.02–1.52) | 0.033 | 1.30 (1.06–1.59) | 0.012 | ||
| The largest tumor diameter, per 1 cm increase | 1.03 (0.99–1.07) | 0.111 | ||||
| MVI (refer to absent) | 1.43 (0.99–2.05) | 0.054 | 1.42 (0.97–2.10) | 0.075 | ||
| EHS (refer to absent) | 1.38 (0.97–1.99) | 0.078 | 1.41 (0.97–2.05) | 0.071 | ||
| Ascites (refer to absent) | 1.88 (1.27–2.77) | 0.002 | 1.70 (1.14–2.55) | 0.01 | ||
| AFP (refer to ≤200 ng/mL) | 2.04 (1.40–3.00) | <0.001 | 1.93 (1.31–2.85) | 0.001 | ||
| ALB, per 1 g/L increase | 0.98 (0.95–1.02) | 0.232 | ||||
| TBIL, per 1 µmol/L increase | 1.01 (1.00–1.02) | 0.029 | 1.014 (1.001–1.03) | 0.032 | ||
| AST, per 1 U/L increase | 1.00 (0.999–1.001) | 0.851 | ||||
| ALT, per 1 U/L increase | 1.00 (0.997–1.003) | 0.849 | ||||
| BUN, perl mmol/L increase | 1.00 (0.914–1.098) | 0.968 | ||||
| Cr, per 1 µmol/L increase | 1.00 (0.99–1.01) | 0.966 | ||||
| WBC, per 1.0 × 109/L increase | 0.98 (0.91–1.06) | 0.614 | ||||
| INR, per 1% increase | 2.09 (0.61–7.14) | 0.240 | ||||
| LEN + DEB-TACE (refer to LEN) | 0.57 (0.39–0.82) | 0.003 | 0.53 (0.36–0.78) | 0.001 | 0.52 (0.36–0.76) | 0.001 |
AFP.alpha-fetoprotein; ALB, albumin; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BCLC, Barcelona Clinic Liver Cancer; BUN, blood urea nitrogen; Cr, creatinine; DEB-TACE, drug-eluting bead transarterial chemoembolization; ECOG, Eastern Cooperative Oncology Group; EHS, extrahepatic spread; HBV, hepatic B virus; HR, hazard ratio; INR, international normalized ratio; IQR, interquartile range; LEN, lenvatinib; LT, liver transplantation; MVI, macrovascular invasion; PLT, platelet; PS, performance status; TBIL, total bilirubin; WBC, white blood cell.