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. 2022 Jul 18;5(7):e2222249. doi: 10.1001/jamanetworkopen.2022.22249

Table 1. NNNS Profiles z Scoresa.

NNNS summary score Profile 1 (n = 79 [11.6%]) Profile 2 (n = 209 [30.7%]) Profile 3 (n = 78 [11.5%]) Profile 4 (n = 108 [15.9%]) Profile 5 (n = 158 [23.3%])b Profile 6 (n = 47 [6.9%])b
Attention 1.33 −0.17 −0.26 0.49 −0.49 −0.48
Handling −0.17 −0.51 0.79 0.54 −0.22 0.72
Regulation 1.32 0.23 −0.79 0.58 −0.50 −1.55
Arousal −0.88 −0.30 1.34 0.27 −0.40 1.29
Excitability −0.53 −0.64 1.13 0.01 −0.14 2.32
Lethargy −0.32 0.14 −0.47 −0.64 0.74 −0.35
Hypertonicity −0.08 −0.14 0.43 −0.16 −0.14 0.85
Hypotonicity −0.34 −0.16 −0.14 −0.32 0.67 −0.02
Nonoptimal reflexes −0.55 −0.24 −0.26 −0.63 1.05 0.35
Asymmetric reflexes 0.57 −0.43 −0.53 0.82 −0.04 0.07
Quality of movement 0.75 0.43 0.38 −0.08 −0.57 −1.69
Stress abstinence −0.30 −0.66 0.16 0.51 0.25 1.16

Abbreviation: NNNS, Neonatal Intensive Care Unit Network Neurobehavioral Scale.

a

Infants with profile 1 had scores that reflect sustained, focused attention and well-modulated arousal tone, movement quality, and self-regulation; they required average handling assistance to sustain alertness. Infants with profile 2 had the fewest stress indicators and predominantly average performance on remaining scores. Infants with profile 3 required more handling assistance and had less self-regulation, with higher arousal and excitability. Infants with profile 4 needed increased handling assistance but showed modulated attention, tone, and self-regulation. Infants with profile 5 (a high behavioral risk profile) showed poorly sustained attention, low arousal with the most lethargy and hypotonia, and increased numbers of nonoptimal reflexes. Infants with profile 6 (a high behavioral risk profile) showed poorly sustained attention, self-regulation, and quality of movement in addition to extremely high levels of arousal, excitability, hypertonicity, and stress signs.

b

High behavioral risk profiles.