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. 2022 Jul 18;79(9):846–855. doi: 10.1001/jamaneurol.2022.1858

Table 1. Randomized Clinical Trials Not Included in the Quantitative Results of the Systematic Review.

Source No. of patients Comparators Main outcome Reason for study exclusion Main results
Babin et al,11 1984 77 Scopolamine vs meclizine vs placebo Global vertigo, frequency of attacks No result details, only P values; authors unavailable or could not provide additional detail Both antihistamines better than placebo
Barzegari et al,12 2016 113 Diazepam vs methylprednisolone Dizziness severity at 30, 60, and 120 min Data not presented in useable form; authors unavailable or could not provide additional detail Less severity of vertigo at 2 h with diazepam compared with methylprednisolone
Herndon et al,13 1975 17 Combination pill of pheniramine, nicotine acid, and pentylenetetrazol vs placebo Nystagmus and vertigo scores No results details; describes “lower” scores, but no raw numbers or data; authors unavailable or could not provide additional detail Combination pill resulted in lower vertigo and nystagmus scores at 1 wk
Jalali et al,14 2020 117 Betahistine vs dimenhydrinate vs placebo Scores on Dizziness Handicap Inventory and modified Berg Balance Scale No outcomes of interest; results not presented in useable manner; authors unavailable or could not provide additional detail Betahistine treatment resulted in greater improvement in dizziness scores
Kulcu et al,15 2008 38 Betahistine vs head and eye (modified Cawthorne-Cooksey) exercises Multiple vertigo scales Data presented as P values and graphs, without raw numbers or data; authors unavailable or could not provide additional detail No difference in vertigo scores at 1 mo, but scores favored exercises at 2 mo
Massaeli et al,16 2017 100 Promethazine vs diazepam Rate of complete resolution 15 min after injection; “duration of vertigo disappearance” Results at unclear acute time frames; no VAS or vertigo rating; no outcomes of interest No significant difference found regarding incidence of primary and secondary outcomes
Mulch et al,17 1976 50 High-dose vs low-dose sulpiride vs diazepam vs dimenhydrinate vs placebo Nystagmus scores No clinical outcomes reported, only nystagmus High-dose sulpiride and dimenhydrinate suppressed nystagmus; diazepam, placebo, and low-dose sulpiride did not
Salvinelli et al,18 2004 156 Semont liberatory maneuver vs flunarizine vs no treatment “Cure” and recurrence at 6 mo Results only provided for 6-mo outcomes; authors unavailable or could not provide additional detail Cure rate of 94% (49 of 52 patients) with Semont, 58% (30 of 52) with flunarizine, and 36% (18 of 53) with no treatment; all differences were statistically significant
Shafipour et al,19 2017 150 Diazepam vs promethazine Vertigo VAS scores at 30, 120, and 240 min VAS outcome was not provided with SD so could not be included in primary meta-analysis; authors unavailable or could not provide additional detail Change in VAS at 2 h: 31.1 with diazepam vs 44.3 with promethazine; difference statistically significant
Singh et al,20 1998 100 Cinnarizine vs prochlorperazine Scale or score not defined, but reports percentage of subjective improvement Not enough detail in results to use in meta-analysis; author contact information unavailable At 5 wk, the average improvement in patients treated with cinnarizine plus exercises was 97%; with prochlorperazine plus exercises, the average improvement was 100%

Abbreviation: VAS, visual analog scale.