Table 1. Randomized Clinical Trials Not Included in the Quantitative Results of the Systematic Review.
Source | No. of patients | Comparators | Main outcome | Reason for study exclusion | Main results |
---|---|---|---|---|---|
Babin et al,11 1984 | 77 | Scopolamine vs meclizine vs placebo | Global vertigo, frequency of attacks | No result details, only P values; authors unavailable or could not provide additional detail | Both antihistamines better than placebo |
Barzegari et al,12 2016 | 113 | Diazepam vs methylprednisolone | Dizziness severity at 30, 60, and 120 min | Data not presented in useable form; authors unavailable or could not provide additional detail | Less severity of vertigo at 2 h with diazepam compared with methylprednisolone |
Herndon et al,13 1975 | 17 | Combination pill of pheniramine, nicotine acid, and pentylenetetrazol vs placebo | Nystagmus and vertigo scores | No results details; describes “lower” scores, but no raw numbers or data; authors unavailable or could not provide additional detail | Combination pill resulted in lower vertigo and nystagmus scores at 1 wk |
Jalali et al,14 2020 | 117 | Betahistine vs dimenhydrinate vs placebo | Scores on Dizziness Handicap Inventory and modified Berg Balance Scale | No outcomes of interest; results not presented in useable manner; authors unavailable or could not provide additional detail | Betahistine treatment resulted in greater improvement in dizziness scores |
Kulcu et al,15 2008 | 38 | Betahistine vs head and eye (modified Cawthorne-Cooksey) exercises | Multiple vertigo scales | Data presented as P values and graphs, without raw numbers or data; authors unavailable or could not provide additional detail | No difference in vertigo scores at 1 mo, but scores favored exercises at 2 mo |
Massaeli et al,16 2017 | 100 | Promethazine vs diazepam | Rate of complete resolution 15 min after injection; “duration of vertigo disappearance” | Results at unclear acute time frames; no VAS or vertigo rating; no outcomes of interest | No significant difference found regarding incidence of primary and secondary outcomes |
Mulch et al,17 1976 | 50 | High-dose vs low-dose sulpiride vs diazepam vs dimenhydrinate vs placebo | Nystagmus scores | No clinical outcomes reported, only nystagmus | High-dose sulpiride and dimenhydrinate suppressed nystagmus; diazepam, placebo, and low-dose sulpiride did not |
Salvinelli et al,18 2004 | 156 | Semont liberatory maneuver vs flunarizine vs no treatment | “Cure” and recurrence at 6 mo | Results only provided for 6-mo outcomes; authors unavailable or could not provide additional detail | Cure rate of 94% (49 of 52 patients) with Semont, 58% (30 of 52) with flunarizine, and 36% (18 of 53) with no treatment; all differences were statistically significant |
Shafipour et al,19 2017 | 150 | Diazepam vs promethazine | Vertigo VAS scores at 30, 120, and 240 min | VAS outcome was not provided with SD so could not be included in primary meta-analysis; authors unavailable or could not provide additional detail | Change in VAS at 2 h: 31.1 with diazepam vs 44.3 with promethazine; difference statistically significant |
Singh et al,20 1998 | 100 | Cinnarizine vs prochlorperazine | Scale or score not defined, but reports percentage of subjective improvement | Not enough detail in results to use in meta-analysis; author contact information unavailable | At 5 wk, the average improvement in patients treated with cinnarizine plus exercises was 97%; with prochlorperazine plus exercises, the average improvement was 100% |
Abbreviation: VAS, visual analog scale.